Regulation of Autophagy by the Neuropathological Protein Tdp-43
نویسندگان
چکیده
NEUROPATHOLOGICAL PROTEIN TDP-43 Jayarama Krishnan Bose, Chi-Chen Huang and C.-K. James Shen Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China Running head: TDP-43 and Autophagy Address correspondence to: C.-K. James Shen, PhD, N523, Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Sec 2, Nangang, Taipei-115, Taiwan, ROC. Tel: +886-2-2789-9194; Fax: +886-2-2651-8055; E-mail: [email protected]
منابع مشابه
Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.
TDP-43 (also known as TARDBP) is a pathological signature protein of neurodegenerative diseases, with TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD)-TDP and amyotrophic lateral sclerosis (ALS)-TDP. These TDP-43 proteinopathies are characterized by cytoplasmic insoluble TDP-43-positive aggregates in the diseased cells, the formation of which requires the seeding of TDP...
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تاریخ انتشار 2011